姓名：孙钦儒

 

研究方向：

法医物证学；

损伤与死亡疑难证据鉴识研究；

法医组学研究与应用；

线粒体稳态在神经损伤中的机制。

 

教育背景：

2005.9-2014.9          西安交通大学  医学博士

2012.8-2013.4          美国堪萨斯大学    研究助理

2011.3-2012.7          美国堪萨斯大学    联合培养博士

2010.3-2011.2          美国哥伦比亚大学  联合培养博士

2000.9-2005.7          西安交通大学  医学学士

 

工作经历：

2021.01-现在 西安交通大学医学部法医学院 副教授

2014.10-2020.12 西安交通大学医学部法医学院 讲师

 

讲授课程：

本科生《法医物证学》、《法医学》、《生物化学》、《分子生物学》

研究生《基因检测与分析》、《医用生物信息基础》

 

科研项目：

主持国家和省部级等课题12项：

1.国家重点研发计划子课题，2022.5-2025.4,178万元

2.国家自然科学基金青年项目（81500927），2016.01-2018.12，17.5万元

3.GF科技创新特区“火花课题”，2020.11-2021.11，30万元

4.陕西省重点研发计划一般项目（2020SF-133），2020.1-2021.12，8万元

5.陕西省自然科学基金面上项目（2017JM8017），2017.01-2018.12，5万元

6.中国博士后基金特别资助（2018T111074），2018.03-2019.12，15万元

7.中国博士后基金面上项目（2017M623190），2017.10-2019.03，5万元

8.陕西省博士后科研项目资助（2018BSHERZZ97），2018.03-2019.08，5万元

9.西安交通大学基本科研业务费（xzy012020084），2020.09-2022.12，9万元

10.西安交通大学省重点实验室开放基金项目，2019.08-2021.07，2万元

11.西安交通大学省重点实验室青年学术骨干培植项目，2015.09-2016.09，15万元

12.西安交通大学“新教师科研支持计划”，2015.04-2017.04，15万元

 

学术成果：

  1. GongjiWang, Wumin Cai, HaoWu, CanyuYang, KaiYu, Ruina Liu, XinWei, Hancheng Lin, Qinru Sun*, ZhenyuanWang*.Identification of human and non-human bloodstains on rough carriers based on ATR-FTIR and chemometrics. Microchemical Journal. Available online 24 May 2022, 107620 (*co-corresponding author) (IF:4.821, 2021)
  2. Hao Wu, Zefeng Li, Xinggong Liang, Run Chen, Kai Yu, Xin Wei, Gongji Wang, Wumin Cai, Huiyu Li, Qinru Sun*, ZhenyuanWang*.Pathological and ATR-FTIR spectral changes of delayed splenic rupture and medical significance. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 5 October 2022, 121286. (*co-corresponding author) (IF:4.098, 2021)
  3. Jiahao Wang, Jiamiao Shi, Ning Jia*, Qinru Sun*. Network pharmacology analysis reveals neuroprotection of Gynostemma pentaphyllum (Thunb.) Makino in Alzheimer' disease. BMC Complement Med Ther. 2022 Mar 7;22(1):57.
  4. Xinru Gao, Jiahao Wang, Jiamiao Shi, Qinru Sun, Ning Jia*, Hui Li*.The Efficacy Mechanism of Epigallocatechin Gallate against Pre-Eclampsia based on Network Pharmacology and Molecular Docking.Reprod Sci. 2022 Jun;29(6):1859-1873. (IF:3.060, 2020)
  5. Wumin Cai, Gongji Wang, Hao Wu, Huiyu Li, Chen Shen, Xin Wei, Kai Yu, Qinru Sun*, ZhenyuanWang*. Identifying traumatic brain injury (TBI) by ATR-FTIR spectroscopy in a mouse model. Spectrochim Acta A Mol Biomol Spectrosc.doi: doi.org/10.1016/j.saa.2022.121099. (*co-corresponding author)(IF:3.232, 2020)
  6. Xin Wei, Kai Yu, Hao Wu, Chen Shen, Huiyu Li, Ruina Liu, Qinru Sun*, Zhenyuan Wang*. Species identification of teeth of human and non-human. Forensic Sci Int, 2022 Jan 26;333:111205. doi: 10.1016/j.forsciint.2022.111205. (*co-corresponding author)(IF:2.395, 2020)
  7. Ruina Liu, Qi Wang, Kai Zhang, Hao Wu, Gongji Wang, Wumin Cai, Kai Yu, Qinru Sun*, Shuanliang Fan*, Zhenyuan, Wang*. Analysis of Postmortem Intestinal Microbiota Successional Patterns with Application in Postmortem Interval Estimation, Microb Ecol . 2021 Nov 13. doi: 10.1007/s00248-021-01923-4 (*co-corresponding author)(IF:4.552, 2020)
  8. XiaorongYang, XinWei, KaiYu, ChangwuWan, YuanheWang, ShimeiHuang, QinruSun*, JiangHuang*. Identification of myocardial fibrosis by ATR-FTIR spectroscopy combined with chemometrics, Spectrochim Acta A Mol Biomol Spectrosc. Volume 264, 5 January 2022, 120238. (*co-corresponding author)(IF:3.232, 2020)
  9. Kai Yu, Hao Wu, Chen Shen, Huiyu Li, Xin Wei, Ruina Liu, Wumin Cai, Gongji Wang, Qinru Sun*, Zhenyuan Wang*. Identification of antemortem and postmortem fractures in a complex environment by FTIR spectroscopy based on a rabbit tibial fracture self-control model. International Journal of Legal Medicine (2021), (*co-corresponding author)(IF:2.222, 2019)
  10. Sheng Li# , Guoan Zhang#, Yanping Liu#, Qinru Sun#, Lu Yang, Junli Dong, Bowen Zhang, Su Chen*. In vitro ubiquitination and degradation of bacteria-purified human histone H2B by the nucleoli fractions. STAR Protoc, . 2021 Jun 11;2(2):100601. (#co-first author)
  11. KaiYu, HaohuiZhang, Yuzhe Liu, HaoWu, Wumin Cai, XinWei, Ruina Liu, Gongji Wang, Qinru Sun*, Zhenyuan Wang*, Adipose tissue estimates the postmortem interval based on ATR-FTIR spectroscopy, Microchemical Journal, doi.org/10.1016/j.microc.2021.105977, (*co-corresponding author)(IF:3.594, 2019)
  12. Qinru Sun, Ning Jia* , Fei Ren, Xin Li, Grape seed proanthocyanidins improves depression-like behavior by alleviating oxidative stress and NLRP3 activation in the hippocampus of prenatally-stressed female offspring rats, J Histotechnol . 2021 Jan 11;1-9 (IF: 0.343, 2019, invited paper)
  13. Xin Wei, Kai Yu, Di Wu, Ping Huang, Qinru Sun*, Zhenyuan Wang*, Species identification of semen stains by ATR-FTIR spectroscopy, Int J Legal Med, 2020 Jul 10. doi: 10.1007/s00414-020-02367-0, (*co-corresponding author)(IF:2.222, 2019)
  14. Kai Yu, Gongji Wang, Wumin Cai, Di Wu, Xin Wei, Kai Zhang, Ruina Liu, Qinru Sun*, Zhenyuan Wang*, Identification of antemortem, perimortem and postmortem fractures by FTIR spectroscopy based on a rabbit tibial fracture model, Spectrochim Acta A Mol Biomol Spectrosc. 2020 Oct 5;239:118535. (*co-corresponding author)(IF:3.232, 2019)
  15. Ruina Liu#, Yuexi Gu#, Mingwang Shen#, Huan Li, Kai Zhang, Qi Wang, Xin Wei, Haohui Zhang, Di Wu, Kai Yu, Wumin Cai, Gongji Wang, Siruo Zhang, Qinru Sun*, Ping Huang*, Zhenyuan Wang*, Predicting postmortem interval based on microbial community sequences and machine learning algorithms, Environment Microbiology, 2020 Jun;22(6):2273-2291. (*co-corresponding author) (IF:5.15, 2019)
  16. Yufei Wang, Lu Yang, Xiaojun Zhang, Wen Cui, Yanping Liu, Qinru Sun, Qing He, Shiyan Zhao, Guo-An Zhang, Yequan Wang, Su Chen*. Epigenetic Regulation of Ferroptosis by H2B Monoubiquitination and p53. EMBO Rep. 2019 Jul;20(7):e47563 (IF:8.383, 2019)
  17. Qinru Sun, Ning Jia*, Xin Li, Jie Yang, Guomin Chen, Grape seed proanthocyanidins ameliorate neuronal oxidative damage by inhibiting GSK-3β-dependent mitochondrial permeability transition pore opening in an experimental model of sporadic Alzheimer’s disease. Aging (Albany NY). 2019 June 4;11(12):4107-4124 (IF:5.515, 2018)
  18. Yu Q, Wang Y, Du F, Yan S, Hu G, Origlia N, Rutigliano G, Sun Q, Yu H, Ainge J, Yan SF, Gunn-Moore F, Yan SS*. Overexpression of endophilin A1 exacerbates synaptic alterations in a mouse model of Alzheimer's disease. Nat Commun. 2018 Jul 30;9(1):2968（IF：12.353, 2017）
  19. Qinru Sun; Ning Jia* ; Jie Yang; Guomin Chen. Nrf2 Signaling Pathway Mediates the Antioxidative Effects of Taurine Against Corticosterone-Induced Cell Death in HUMAN SK-N-SH Cells, Neurochem Res, 2018.2.10, 43(2): 276~286 （IF：2.772, 2017）
  20. Jia N*, Sun Q*, Su Q, Dang S, Chen G. Taurine promotes cognitive function in prenatally stressed juvenile rats via activating the Akt-CREB-PGC1α pathway. Redox Biol. 2016 Dec;10:179-190  (*co-corresponding author)（IF：6.235, 2016）
  21. Jia N*, Sun Q*, Su Q, Chen G. SIRT1-mediated deacetylation of PGC1α attributes to the protection of curcumin against glutamate excitotoxicity in cortical neurons. Biochem Biophys Res Commun. 2016 Sep 23;478(3):1376-81 (*co-corresponding author) （IF：2.371, 2016）
  22. Valasani KR#, Sun Q#, Fang D, Zhang Z, Yu Q, Guo Y, Li J, Roy A, ShiDu Yan S. Identification of a Small Molecule Cyclophilin D Inhibitor for Rescuing Aβ-Mediated Mitochondrial Dysfunction. ACS Med Chem Lett. 2016 Jan 6;7(3):294-9 （# co-first author）（IF：3.355, 2016）
  23. Fang D, Wang Y, Zhang Z, Du H, Yan S, Sun Q, Zhong C, Wu L, Vangavaragu JR, Yan S, Hu G, Guo L, Rabinowitz M, Glaser E, Arancio O, Sosunov AA, McKhann GM, Chen JX, Yan SS*. Increased neuronal PreP activity reduces Aβ accumulation, attenuates neuroinflammation and improves mitochondrial and synaptic function in Alzheimer disease's mouse model. Hum Mol Genet. 2015 Sep 15;24(18):5198-210（IF：5.985, 2016）
  24. Jia N, Li Q, Sun H, Song Q, Tang G, Sun Q, Wang W, Chen R, Li H, Zhu Z*. Alterations of Group I mGluRs and BDNF Associated with Behavioral Abnormity in Prenatally Stressed Offspring Rats[J]. Neurochem Res. 2015 May;40(5):1074-82. （IF：2.472, 2016）
  25. Sun Q, Jia N*, Wang W, Jin H, Xu J, Hu H*. Protective Effects of Astragaloside IV against Amyloid Beta1-42 Neurotoxicity by Inhibiting the Mitochondrial Permeability Transition Pore Opening[J]. PLoS One. 2014, Jun 6;9(6):e98866. （IF：3.234, 2014）
  26. Sun Q, Hu H, Wang W, Jin H, Feng G, Jia N*. Taurine attenuates amyloid β 1-42-induced mitochondrial dysfunction by activating of SIRT1 in SK-N-SH cells[J]. Biochem Biophys Res Commun, 2014, 447 (3): 485–489. （IF：2.297, 2014）
  27. Sun Q#, Jia N#, Wang W, Jin H, Xu J, Hu H*. Activation of SIRT1 by curcumin blocks the neurotoxicity of amyloid-<beta>25-35 in rat cortical neurons[J]. Biochem Biophys Res Commun, 2014 ,448(1):89-94. （# co-first author）（IF：IF：2.297, 2014）
  28. Valaasani KR#, Sun Q#, Hu G, Li J, Du F, Guo Y, Carlson EA, Gan X, Yan SS. Identification of Human ABAD Inhibitors for Rescuing Abeta-Mediated Mitochondrial Dysfunction[J]. Curr Alzheimer Res, 2014, 11 (2): 128-136. (#co-first author) （IF：3.889, 2014）
  29. Liu T, Jin H, Sun QR, Xu JH, Hu HT*. Neuroprotective effects of emodin in rat cortical neurons against beta-amyloid-induced neurotoxicity[J]. Brain Res, 2010, 1347: 149-160.（IF：2.623, 2011）
  30. Liu T, Jin H, Sun QR, Xu JH, Hu HT*. The neuroprotective effects of tanshinone IIA on beta-amyloid-induced toxicity in rat cortical neurons[J]. Neuropharmacology, 2010, 59 (7-8): 595-604. （IF：4.677, 2011）
  31. Jin H, Liu T, Wang WX, Xu JH, Yang PB, Lu HX, Sun QR, Hu HT*. Protective effects of [Gly14]-Humanin on beta-amyloid-induced PC12 cell death by preventing mitochondrial dysfunction[J]. Neurochem Int, 2010, 56 (3): 417-423.（IF：3.601, 2011）
  32. Jia N, Yang K, Sun Q, Cai Q, Li H, Cheng D, Fan X, Zhu Z*. Prenatal stress causes dendritic atrophy of pyramidal neurons in hippocampal CA3 region by glutamate in offspring rats[J]. Dev Neurobiol, 2010, 70 (2): 114-125. （IF：2.885, 2011）

 

联系方式：

邮箱：qinrusun@xjtu.edu.cn